Two third-year right-handers -- Chicago's Reynaldo Lopez and Oakland's Daniel Mengden -- are scheduled to be the starting pitchers.
Lopez, coming off two impressive starts, has been the listed starter the past three days, only to have those three games at Minnesota postponed because of bad weather.
He has not pitched since eight days ago, when he limited the Detroit Tigers to two hits and one unearned run in a 1-0 loss.
Lopez was similarly sharp in his season debut, holding the Toronto Blue Jays to two hits and one run, only to see the White Sox lose that game as well, 4-2.
Weather permitting, Lopez will take an 0-1 record and a 0.69 ERA to the mound in his first career start against Oakland.
Mengden, likewise, has never faced the White Sox. And like Lopez, who was acquired from Washington in 2016 for Adam Eaton, he was the prospect imported when the A's sent Scott Kazmir to Houston in 2015.
But the similarities between the two starters end there.
Mengden (1-2, 6.19) has been roughed up in all three starts, with the A's opponent having scored at least six runs in all three games.
He escaped with a win in his last start when Oakland exploded for 16 runs in a 16-6 victory over the Los Angeles Dodgers on Wednesday.
That game was on the road.
Mengden has gotten far less support -- both offensively and defensively -- at home, where he has yet to win in 13 career starts, going 0-10.
The A's have made one key error in each of his two home starts this season, leading to an unearned run in each.
"I can only control what I can control, and that's executing and making pitches," Mengden said. "We all want to play well all the way around. I know some of the guys wish they made better plays, and I wish I made better pitches, but that's baseball."
The closest the White Sox have come to baseball in the last three days has been indoor workouts on Friday and Saturday after snow/rainouts in Minnesota. They completed the hat trick with a third straight washout Sunday.
They've won just twice in 10 games since a 2-0 start.
"We all know that in a long season, you are going to have ups and downs," White Sox standout Jose Abreu said of the team's slow start as much as its choppy schedule. "The only way to get over it is to keep your mind positive and to have confidence in yourself and the guys that are around you. That has been my message for all the guys, and we're good."
The A's had lost four of five before Sean Manaea outpitched Felix Hernandez in a 2-1 win in the series finale Sunday at Seattle.